Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

Chem Commun (Camb). 2013 Jun 18;49(48):5492-4. doi: 10.1039/c3cc41278d. Epub 2013 May 10.

Abstract

An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / metabolism
  • Crystallography, X-Ray
  • Matrix Metalloproteinase 3 / chemistry
  • Matrix Metalloproteinase 3 / metabolism*
  • Matrix Metalloproteinase Inhibitors / chemistry*
  • Matrix Metalloproteinase Inhibitors / metabolism
  • Platinum / chemistry*
  • Protein Binding
  • Protein Structure, Tertiary

Substances

  • Coordination Complexes
  • Matrix Metalloproteinase Inhibitors
  • Platinum
  • Matrix Metalloproteinase 3

Associated data

  • PDB/4DPE
  • PDB/4G9L
  • PDB/4JA1