Decreasing cardiovascular risk factors in obese individuals using a combination of PGX® meal replacements and PGX® granules in a 12-week clinical weight modification program

J Complement Integr Med. 2013 May 7:10:/j/jcim.2013.10.issue-1/jcim-2012-0003/jcim-2013-0003.xml. doi: 10.1515/jcim-2013-0003.

Abstract

In this open, clinically based, weight modification program, we determined in six sedentary obese adults (five women; one male; age range 30-62 years) that the combination of a modified calorie diet plus PGX® meal replacement and PGX® supplementation resulted in a significant reduction in several cardiovascular risk factors over a 12-week time period. This included a significant improvement in lipids (-0.98 mmol/l LDL-C), reduction in average weight (-9.2 kg), mean reduction in fat (-4.1%) and an increase in fat-free mass (2.8%).

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Adult
  • Alginates / pharmacology
  • Alginates / therapeutic use
  • Body Composition / drug effects*
  • Body Fluid Compartments / drug effects
  • Caloric Restriction*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Cholesterol, LDL / blood
  • Diet, Reducing
  • Dietary Fiber / pharmacology
  • Dietary Fiber / therapeutic use*
  • Dietary Supplements
  • Female
  • Glucuronic Acid / pharmacology
  • Glucuronic Acid / therapeutic use
  • Hexuronic Acids / pharmacology
  • Hexuronic Acids / therapeutic use
  • Humans
  • Male
  • Mannans / pharmacology
  • Mannans / therapeutic use
  • Middle Aged
  • Obesity / blood
  • Obesity / diet therapy*
  • Polysaccharides, Bacterial / pharmacology
  • Polysaccharides, Bacterial / therapeutic use
  • Risk Factors
  • Sedentary Behavior
  • Weight Loss / drug effects*
  • Weight Reduction Programs*

Substances

  • Alginates
  • Cholesterol, LDL
  • Dietary Fiber
  • Hexuronic Acids
  • Mannans
  • Polysaccharides, Bacterial
  • (1-6)-alpha-glucomannan
  • Glucuronic Acid
  • xanthan gum