Abstract
Hollow microcapsules capable of disintegrating in response to dual biological stimuli have been synthesized from two FDA approved drug molecules. The capsules fabricated from protamine and chondroitin sulphate disintegrate in the presence of either trypsin or hyaluronidase enzymes, which are documented to be simultaneously over-expressed under some pathological conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium Carbonate / chemistry
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Capsules
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Chondroitin Sulfates / chemistry*
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Drug Delivery Systems*
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Hyaluronoglucosaminidase / chemistry*
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Polystyrenes / chemistry
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Protamines / chemistry*
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Trypsin / chemistry*
Substances
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Capsules
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Polystyrenes
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Protamines
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polystyrene sulfonic acid
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Chondroitin Sulfates
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Hyaluronoglucosaminidase
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Trypsin
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Calcium Carbonate