Abstract
Synthetic iridium-, rhodium-, and ruthenium-amino acid complexes with hydrophobic l-amino acids have antibiotic activity against Mycobacterium spp., including Mycobacterium bovis BCG and the rapidly growing species Mycobacterium abscessus and Mycobacterium chelonae. Concentrations of transition metal-amino acid complexes demonstrating hemolysis or cytotoxicity were 10- to 25-fold higher than were the MICs.
MeSH terms
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Amino Acids / chemistry
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Amino Acids / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Coordination Complexes / pharmacology*
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Iridium / chemistry
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Iridium / pharmacology
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Microbial Sensitivity Tests
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Mycobacterium / drug effects*
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Rhodium / chemistry
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Rhodium / pharmacology
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Ruthenium / chemistry
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Ruthenium / pharmacology
Substances
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Amino Acids
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Anti-Bacterial Agents
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Coordination Complexes
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Iridium
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Ruthenium
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Rhodium