Abstract
A new class of mono and bis heterocycles, sulfonylmethaneamido linked oxazoles, thiazoles, imidazoles, pyrrolyl oxazoles, pyrrolyl thiazoles and pyrrolyl imidazoles were prepared adopting simple and versatile synthetic methodologies. The compound chloro substituted imidazolyl styrylsulfonylacetamide is the most potent antimicrobial agent particularly against Pseudomonas aeruginosa and Penicillium chrysogenum.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology*
-
Azoles / chemical synthesis
-
Azoles / chemistry
-
Azoles / pharmacology*
-
Dose-Response Relationship, Drug
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Penicillium chrysogenum / drug effects*
-
Pseudomonas aeruginosa / drug effects*
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Azoles