Abstract
In this work we reported the synthesis and evaluation of in vitro antimicrobial activities of hydrazones 6 obtained from 3-oxido-1H-imidazole-4-carbohydrazides 4. All new compounds were characterized by spectroscopic methods. Hydrazones 6 were tested for their in vitro antimicrobial activity against four Gram-positive and four Gram-negative strains of bacteria as well as one fungal species. Three of the tested compounds appeared to be promising agents against reference strains of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. They were also tested against twelve clinical isolates of S. aureus and their cytotoxic effect on murine fibroblasts and HeLa human tumor cell line was determined.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / growth & development
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Cell Line
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cyclic N-Oxides / chemistry*
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Fungi / drug effects*
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Fungi / growth & development
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HeLa Cells
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Humans
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Hydrazines / chemistry*
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Hydrazones / chemical synthesis
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Hydrazones / chemistry
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Hydrazones / pharmacology*
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Imidazoles / chemistry*
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Cyclic N-Oxides
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Hydrazines
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Hydrazones
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Imidazoles