Abstract
A novel copper(I) Schiff base complex has been synthesized and fully characterized by spectral, analytical and structural modes. Single crystal X-ray diffraction studies revealed that the copper(I) complex [CuCl(PPh3)L] has a distorted tetrahedral geometry around the central copper(I) ion. The interaction of the ligand and the complex with CT-DNA has been explored by absorption titration method which revealed that the compounds could interact with CT-DNA through intercalation. A gel electrophoresis assay demonstrated the ability of the complex to cleave the pBR322 DNA. The antioxidative properties showed that the copper(I) complex has a strong radical-scavenging potency than ligands. Further the cytotoxic effect of the compounds examined on cancerous cell lines showed that the complex exhibited substantial anticancer activity.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Binding Sites / drug effects
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Cattle
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Coordination Complexes / chemistry*
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Copper / chemistry
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Crystallography, X-Ray
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DNA / chemistry
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DNA / drug effects*
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DNA Cleavage / drug effects
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Dose-Response Relationship, Drug
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Drug Design*
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Drug Screening Assays, Antitumor
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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HeLa Cells
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Humans
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Ligands
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MCF-7 Cells
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Schiff Bases / chemical synthesis
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Schiff Bases / chemistry
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Schiff Bases / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Coordination Complexes
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Free Radical Scavengers
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Ligands
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Organometallic Compounds
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Schiff Bases
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chloro(5-dimethyl-2-phenyl-4-((pyridin-2-ylmethylene)amino)-1,2-dihydro-pyrazol-3-one)(triphenylphosphine)copper(I)
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Copper
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DNA
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calf thymus DNA