Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean-Marie Galano; Emilie Mas; Anne Barden; Trevor A Mori; Cinzia Signorini; Claudio De Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean-Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans

Prostaglandins Other Lipid Mediat. 2013 Dec:107:95-102. doi: 10.1016/j.prostaglandins.2013.04.003. Epub 2013 May 2.

Authors

Jean-Marie Galano¹, Emilie Mas, Anne Barden, Trevor A Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean-Yves Le Guennec, Camille Oger, Thierry Durand

Affiliation

¹ Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 - CNRS - University Montpellier I and II - ENSCM, Faculty of Pharmacy, Montpellier, France.

PMID: 23644158
DOI: 10.1016/j.prostaglandins.2013.04.003

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Keywords: Bioactive lipids; Biomarkers; Isoprostanes; Metabolites; Neuroprostanes; PUFAs.

Publication types

Review

MeSH terms

Animals
Biomarkers / metabolism
Fatty Acids, Omega-3 / metabolism
Hemodynamics
Humans
Isoprostanes / biosynthesis*
Lipid Peroxidation
Neuroprostanes / biosynthesis*
Oxidative Stress*
Reperfusion Injury / metabolism

Substances

Biomarkers
Fatty Acids, Omega-3
Isoprostanes
Neuroprostanes