From the n-BuOH extract of the aerial parts of Genista ulicina, six triterpene saponins, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,30-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3,29-di-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,28,29-triol-27-oic acid, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28-triol-29-oic acid, and 3-O-β-D-glucopyranosyl-14-H-27-nor-olean-12-ene-3β,28,29-triol, were isolated together with eight known triterpene saponins and six flavonoids. Their structures were established mainly by means of spectroscopic methods (1D and 2D-NMR as well as HR-ESI-MS). The n-BuOH extract, investigated for its antitumor growth inhibition of human colon cancer HT-29 cells, presented no significant activity (IC50>100 μg).
Keywords: BJJGORZQELYRDI-KNSQHGMUSA-N; BJJGORZQELYRDI-VROOZBDDSA-N; Cytotoxic activity; Fabaceae; Genista ulicina; HFHHGAGIYCPWEJ-KEKGXROISA-N; MMOWNTHMMVQHSI-POVYRCDXSA-N; Triterpenoid saponins; UTZJXWSFXGRIHE-XHNVEASOSA-N; VUBHEJPEVMGDCH-DNVPAQNPSA-N.
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