Abstract
An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D ((1)H, (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities.
Keywords:
Anti-Bacillus megaterium; Cryptosporiopsis sp.; Endophytic fungus; Lipoxygenase inhibition; Novel polyketide; TDDFT CD calculations.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Ascomycota / chemistry*
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Bacillus megaterium / drug effects*
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Dose-Response Relationship, Drug
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Lipoxygenase / metabolism*
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Lipoxygenase Inhibitors / chemistry
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Lipoxygenase Inhibitors / isolation & purification
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Lipoxygenase Inhibitors / pharmacology*
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Microbial Sensitivity Tests
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Molecular Conformation
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Polyketides / chemistry
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Polyketides / isolation & purification
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Polyketides / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Biological Products
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Lipoxygenase Inhibitors
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Polyketides
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cryptosporioptide
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Lipoxygenase