Abstract
A highly efficient Cu-catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with arylidene malonates using simple, stable, and easily prepared bis-sulfonamide diamine ligands was developed. The desired products were obtained in up to 99% yield with 96% ee.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Catalysis
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Diamines / chemical synthesis*
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Diamines / chemistry
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Indoles / chemistry*
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Ligands
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Malonates / chemistry*
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Mesylates / chemistry*
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Molecular Structure
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
Substances
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Diamines
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Indoles
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Ligands
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Malonates
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Mesylates
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Sulfonamides
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trifluoromethanesulfonic acid