Polyclonal outbreak of KPC-3-producing Enterobacter cloacae at a single hospital in Montreal, Quebec, Canada

J Clin Microbiol. 2013 Jul;51(7):2406-8. doi: 10.1128/JCM.02480-12. Epub 2013 May 1.

Abstract

From September 2010 to December 2011, 26 KPC-3-producing Enterobacter cloacae isolates were identified from 16 patients at a single hospital. Analyses revealed the blaKPC gene to be localized on multiple plasmids in a diverse nonclonal E. cloacae genetic background. These findings highlight the potential complexity of a KPC outbreak at a single hospital.

MeSH terms

  • Cluster Analysis
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Disease Outbreaks*
  • Enterobacter cloacae / classification
  • Enterobacter cloacae / enzymology*
  • Enterobacter cloacae / genetics
  • Enterobacter cloacae / isolation & purification
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology
  • Female
  • Genotype
  • Hospitals
  • Humans
  • Male
  • Molecular Epidemiology
  • Molecular Typing
  • Plasmids
  • Quebec / epidemiology
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-Lactamases
  • beta-lactamase KPC-3, Enterobacter cloacae