Characterization of pKP1433, a novel KPC-2-encoding plasmid from Klebsiella pneumoniae sequence type 340

C C Papagiannitsis; V Miriagou; P Giakkoupi; L S Tzouvelekis; A C Vatopoulos

doi:10.1128/AAC.00054-13

Characterization of pKP1433, a novel KPC-2-encoding plasmid from Klebsiella pneumoniae sequence type 340

Antimicrob Agents Chemother. 2013 Jul;57(7):3427-9. doi: 10.1128/AAC.00054-13. Epub 2013 Apr 29.

Authors

C C Papagiannitsis¹, V Miriagou, P Giakkoupi, L S Tzouvelekis, A C Vatopoulos

Affiliation

¹ Department of Microbiology, National School of Public Health, Athens, Greece. c.papagiannitsis@gmail.com

Abstract

The nucleotide sequence of pKP1433 (55,417 bp), a blaKPC-2-carrying plasmid from Klebsiella pneumoniae sequence type 340, was determined. pKP1433 displayed extensive sequence and structural similarities with the IncN plasmids possessing the KPC-2-encoding Tn4401b isoform. However, the replication, partitioning, and stability of pKP1433 were determined by sequences related to diverse non-IncN plasmids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Klebsiella pneumoniae / genetics*
Molecular Sequence Data
Plasmids / genetics*
Sequence Analysis, DNA
beta-Lactamases / genetics*

Substances

beta-Lactamases
beta-lactamase KPC-2, Klebsiella pneumoniae

Associated data

GENBANK/JX397875