Abstract
An efficient synthesis of the C1-C21 fragment of azaspiracids-1 and -3 is described. This features a Nozaki-Hiyama-Kishi reaction to couple the AB and CD ring precursors and formation of the THF-fused ABCD trioxadispiroketal system under thermodynamic conditions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Furans / chemical synthesis*
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Furans / chemistry
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Marine Toxins / chemical synthesis*
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Marine Toxins / chemistry
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Molecular Structure
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Pyrans / chemical synthesis*
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Pyrans / chemistry
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
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Thermodynamics
Substances
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Furans
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Marine Toxins
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Pyrans
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Spiro Compounds
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azaspiracid
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azaspiracid-2