Organocatalyzed asymmetric synthesis of morphans

Org Lett. 2013 May 17;15(10):2458-61. doi: 10.1021/ol400926p. Epub 2013 Apr 29.

Abstract

A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry*
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Stereoisomerism

Substances

  • Aza Compounds