Abstract
Objective:
To investigate the anticancer effect of curcumin Solid Dispersions (SDs).
Methods:
Curcumin SDs were prepared by patent technology. The anticancer effect of curcumin SDs were investigated by vivo and vitro tests of SCG-7901, BEL-7402, S-180 and Ehrlich ascites tumor models.
Results:
The results showed that Curcumin SDs had markedly anticancer effect and could improve the anticancer effect of cisplatin.
Conclusion:
Curcumin SDs could be developed into one kind of adjuvant drug for anticancer, as it has markedly anticancer effect, and could improve the anticancer effects of cisplatin.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chemistry Techniques, Synthetic
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Cisplatin / administration & dosage
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Cisplatin / pharmacology*
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Curcuma / chemistry
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Curcumin / administration & dosage
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Curcumin / chemistry*
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Curcumin / pharmacology*
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Drug Synergism
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Drug Therapy, Combination
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Humans
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Male
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Mice
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Mice, Inbred BALB C
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Neoplasm Transplantation
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Neoplasms / drug therapy
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Neoplasms / pathology*
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Solubility
Substances
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Antineoplastic Agents, Phytogenic
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Curcumin
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Cisplatin