[Pharmacological researches of curcumin solid dispersions in treatment of cancer]

Zhong Yao Cai. 2012 Oct;35(10):1645-9.
[Article in Chinese]

Abstract

Objective: To investigate the anticancer effect of curcumin Solid Dispersions (SDs).

Methods: Curcumin SDs were prepared by patent technology. The anticancer effect of curcumin SDs were investigated by vivo and vitro tests of SCG-7901, BEL-7402, S-180 and Ehrlich ascites tumor models.

Results: The results showed that Curcumin SDs had markedly anticancer effect and could improve the anticancer effect of cisplatin.

Conclusion: Curcumin SDs could be developed into one kind of adjuvant drug for anticancer, as it has markedly anticancer effect, and could improve the anticancer effects of cisplatin.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Chemistry Techniques, Synthetic
  • Cisplatin / administration & dosage
  • Cisplatin / pharmacology*
  • Curcuma / chemistry
  • Curcumin / administration & dosage
  • Curcumin / chemistry*
  • Curcumin / pharmacology*
  • Drug Synergism
  • Drug Therapy, Combination
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neoplasm Transplantation
  • Neoplasms / drug therapy
  • Neoplasms / pathology*
  • Solubility

Substances

  • Antineoplastic Agents, Phytogenic
  • Curcumin
  • Cisplatin