Abstract
We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives downregulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Aorta / cytology
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Aorta / drug effects*
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Aorta / metabolism
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Cattle
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Endothelial Cells / cytology
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Endothelial Cells / drug effects*
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Endothelial Cells / metabolism
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Gene Expression Regulation
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Humans
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Inhibitory Concentration 50
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Resveratrol
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Stilbenes / chemical synthesis
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Stilbenes / pharmacology*
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Structure-Activity Relationship
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents
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Stilbenes
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Resveratrol