Virulence of pertactin-negative Bordetella pertussis isolates from infants, France

Emerg Infect Dis. 2013 Mar;19(3):471-4. doi: 10.3201/1903.121475.

Abstract

Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between the 2 groups.

Keywords: Bordetella pertussis; acellular vaccines; bacteria; coccobacillus; immunization; pertactin; vaccination; vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Outer Membrane Proteins / metabolism*
  • Bacterial Vaccines
  • Bordetella pertussis / isolation & purification
  • Bordetella pertussis / metabolism
  • Bordetella pertussis / pathogenicity*
  • Female
  • France
  • Humans
  • Infant
  • Male
  • Mass Vaccination
  • Surveys and Questionnaires
  • Virulence
  • Virulence Factors, Bordetella / metabolism*
  • Whooping Cough / microbiology*
  • Whooping Cough / prevention & control

Substances

  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Virulence Factors, Bordetella
  • pertactin