Hepatic carcinosarcoma: clinicopathologic features and a review of the literature

Ann Hepatol. 2013 May-Jun;12(3):495-500.

Abstract

Hepatic carcinosarcoma (HCS) is defined as a malignant tumor containing an intimate mixture of carcinomatous and sarcomatous elements. Here, we report the case of a 72-year-old man who developed HCS from an otherwise normal liver. The patient had no history of alcohol abuse or hepatitis B or C infection. An enhanced abdominal CT scan revealed a 9-cm heterogeneous tumor, with enhancement during the arterial phase and delayed wash-out in the latter phases. Also, a marked elevation in alpha-fetoprotein level (15,164 ng/mL; normal range, < 10 ng/mL) was noted. He underwent resection of liver segments V and VI under a pre-operative diagnosis of atypical hepatocellular carcinoma (HCC). The diagnosis of HCS was made based on thorough pathologic examination with a panel of immunohistochemical staining. Following surgery, the patient made an uneventful recovery, and at present, 16 months post-surgery, he remains well with no evidence of tumor recurrence. In conclusion, pre-operative diagnosis of HCS is difficult and radical resection in the early stage is encouraged to improve the prognosis of these patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biopsy
  • Carcinosarcoma / blood
  • Carcinosarcoma / diagnostic imaging
  • Carcinosarcoma / pathology*
  • Carcinosarcoma / surgery
  • Hepatectomy
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms / blood
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery
  • Male
  • Predictive Value of Tests
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • alpha-Fetoproteins / analysis

Substances

  • AFP protein, human
  • alpha-Fetoproteins