Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice

Sonia R Kameda; Daniela F Fukushiro; Raphael Wuo-Silva; Thaís F Trombin; Roberta Procópio-Souza; Letícia C Brandão; Leandro Sanday; Camilla L Patti; Elisa Mári-Kawamoto; Sergio Tufik; Vânia D'Almeida; Roberto Frussa-Filho

doi:10.1016/j.psychres.2013.03.021

Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice

Psychiatry Res. 2013 Jun 30;208(1):74-7. doi: 10.1016/j.psychres.2013.03.021. Epub 2013 Apr 23.

Authors

Sonia R Kameda¹, Daniela F Fukushiro, Raphael Wuo-Silva, Thaís F Trombin, Roberta Procópio-Souza, Letícia C Brandão, Leandro Sanday, Camilla L Patti, Elisa Mári-Kawamoto, Sergio Tufik, Vânia D'Almeida, Roberto Frussa-Filho

Affiliation

¹ Department of Pharmacology, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062 São Paulo, SP, Brazil.

PMID: 23618352
DOI: 10.1016/j.psychres.2013.03.021

Abstract

We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Animals
Animals, Newborn
Dextroamphetamine / pharmacology*
Disease Models, Animal
Hyperkinesis / chemically induced*
Hypoxia / psychology*
Male
Mice
Schizophrenia / chemically induced*

Substances

Dextroamphetamine