Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity

Int J Mol Sci. 2013 Apr 24;14(5):8890-8. doi: 10.3390/ijms14058890.

Abstract

Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Humans
  • Inhibitory Concentration 50
  • Plant Roots / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • Rosaceae / chemistry*
  • Superoxides / metabolism
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*
  • Young Adult

Substances

  • Anti-Inflammatory Agents
  • Triterpenes
  • Superoxides