The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis

Biosci Biotechnol Biochem. 2013;77(4):860-2. doi: 10.1271/bbb.120791.

Abstract

We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / drug effects
  • Bone Resorption / drug therapy*
  • Cryptoxanthins
  • Disease Models, Animal
  • Humans
  • Inflammation / drug therapy
  • Mice
  • NIH 3T3 Cells
  • Osteoblasts / drug effects
  • Osteoblasts / pathology
  • Osteoclasts / drug effects
  • Osteoclasts / pathology
  • Periodontitis / drug therapy*
  • Periodontitis / pathology
  • Periodontitis / physiopathology*
  • Xanthophylls / pharmacology*
  • Xanthophylls / therapeutic use

Substances

  • Cryptoxanthins
  • Xanthophylls