Abstract
We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.
MeSH terms
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Animals
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Bone Marrow Cells / cytology
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Bone Marrow Cells / drug effects
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Bone Resorption / drug therapy*
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Cryptoxanthins
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Disease Models, Animal
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Humans
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Inflammation / drug therapy
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Mice
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NIH 3T3 Cells
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Osteoblasts / drug effects
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Osteoblasts / pathology
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Osteoclasts / drug effects
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Osteoclasts / pathology
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Periodontitis / drug therapy*
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Periodontitis / pathology
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Periodontitis / physiopathology*
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Xanthophylls / pharmacology*
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Xanthophylls / therapeutic use
Substances
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Cryptoxanthins
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Xanthophylls