Quaternary Ammonium Herbicides (QUATs) are nonselective contact herbicides, widely used at weed emergence to protect a wide range of crops. The benefits achieved by the use of these herbicides are indisputable. In soils devoted to vineyards, their uses increase the yield and the quality of the grapes for winemaking. However, several environmental dangers have emerged from the overuse of these compounds. Therefore, there has been a great interest in the presence of these compounds in soils, water, and food. Once in the soil, the mobility of these agrochemicals plays an important role in their fate and transport in the environment. This is why we mainly focused our review on (a) their physical and chemical properties and their activity, (b) the factors affecting their mobility in soils, (c) the quality of surrounding waters, and (d) the measures to reduce their contamination, especially in the case of agricultural soils devoted to vineyards.