Acute disseminated staphylococcal disease (ADSD) constitutes a potentially fatal and alarmingly increasing disorder. We describe an unusual case of a two-and-a-half-year-old female with community-acquired methicillin-resistant Staphylococcus aureus induced septic shock complicated by osteomyelitis and deep vein thrombosis. Aggressive management with long-term antistaphylococcal therapy, anticoagulation and intensive care support was implemented with complete resolution of disseminated inflammation.