Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor

Adv Drug Deliv Rev. 2013 Nov;65(13-14):1699-715. doi: 10.1016/j.addr.2013.04.011. Epub 2013 Apr 20.

Abstract

Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. The new drug delivery system (DDS) provides promising approaches to reverse MDR, for which the poor cellular uptake and insufficient intracellular drug release remain rate-limiting steps for reaching the drug concentration level within the therapeutic window. Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites. In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed.

Keywords: Chemotherapy; Drug delivery; Multidrug resistance; Responsive; Stimuli; Tumor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use
  • Clinical Trials as Topic
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Drug Resistance, Multiple*
  • Drug Resistance, Neoplasm*
  • Humans
  • Hydrogen-Ion Concentration
  • Light
  • Magnetic Fields
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Oxidation-Reduction
  • Ultrasonics

Substances

  • Antineoplastic Agents
  • Drug Carriers