Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Angew Chem Int Ed Engl. 2013 May 27;52(22):5757-61. doi: 10.1002/anie.201209991. Epub 2013 Apr 22.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Base Sequence
  • Cell Line
  • Drug Delivery Systems*
  • Humans
  • Inflammation / drug therapy*
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Nanoparticles / administration & dosage*
  • Particle Size
  • RNA, Small Interfering / administration & dosage*
  • Tumor Necrosis Factor-alpha / administration & dosage*

Substances

  • RNA, Small Interfering
  • Tumor Necrosis Factor-alpha