Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic KI and Oxone as the terminal oxidant

Chem Commun (Camb). 2013 May 25;49(42):4800-2. doi: 10.1039/c3cc41164h.

Abstract

Isoxazolines can be efficiently synthesized in good yields via a hypoiodite mediated catalytic oxidative cyclization of aldoximes and alkenes. This reaction involves active iodine species generated in situ from catalytic amounts of KI and Oxone.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Cyclization
  • Iodine Compounds / chemistry*
  • Isoxazoles / chemistry*
  • Oxidants / chemistry
  • Oximes / chemistry*
  • Potassium Iodide / chemistry*
  • Sulfuric Acids / chemistry*

Substances

  • Alkenes
  • Iodine Compounds
  • Isoxazoles
  • Oxidants
  • Oximes
  • Sulfuric Acids
  • Potassium Iodide
  • hypoiodous acid
  • potassium peroxymonosulfuric acid