Overcoming cisplatin resistance in chemotherapy by biomineralization

Chem Commun (Camb). 2013 May 28;49(43):4932-4. doi: 10.1039/c3cc41872c.

Abstract

Nano-solidified intermedias (NSI) of cisplatin were prepared via biomineralization and applied to reverse the drug resistance of cancers in vitro and in vivo by an alternative internalization pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Carbonates / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cisplatin / chemistry*
  • Cisplatin / pharmacology
  • Drug Resistance, Neoplasm*
  • Endocytosis
  • Humans
  • Phosphates / chemistry*

Substances

  • Antineoplastic Agents
  • Carbonates
  • Phosphates
  • Cisplatin