Progress in computational studies of host-pathogen interactions

J Bioinform Comput Biol. 2013 Apr;11(2):1230001. doi: 10.1142/S0219720012300018. Epub 2012 Oct 24.

Abstract

Host-pathogen interactions are important for understanding infection mechanism and developing better treatment and prevention of infectious diseases. Many computational studies on host-pathogen interactions have been published. Here, we review recent progress and results in this field and provide a systematic summary, comparison and discussion of computational studies on host-pathogen interactions, including prediction and analysis of host-pathogen protein-protein interactions; basic principles revealed from host-pathogen interactions; and database and software tools for host-pathogen interaction data collection, integration and analysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Artificial Intelligence
  • Communicable Diseases / etiology
  • Computational Biology
  • Databases, Protein
  • Gene Expression
  • Host-Pathogen Interactions* / genetics
  • Host-Pathogen Interactions* / physiology
  • Human Immunodeficiency Virus Proteins / chemistry
  • Human Immunodeficiency Virus Proteins / physiology
  • Humans
  • Models, Biological
  • Protein Interaction Mapping / statistics & numerical data*
  • Protozoan Proteins / chemistry
  • Protozoan Proteins / physiology
  • RNA Interference
  • Software
  • Structural Homology, Protein

Substances

  • Human Immunodeficiency Virus Proteins
  • Protozoan Proteins