A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

Chem Commun (Camb). 2013 May 25;49(42):4785-7. doi: 10.1039/c3cc38604j.

Abstract

Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / metabolism
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Survival / drug effects
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • DNA / metabolism
  • Embryo, Nonmammalian / drug effects
  • HT29 Cells
  • Humans
  • Ligands
  • MCF-7 Cells
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Titanium / chemistry
  • Titanium / pharmacology*
  • Zebrafish

Substances

  • Albumins
  • Antineoplastic Agents
  • Coordination Complexes
  • Ligands
  • Organometallic Compounds
  • Titanocene Y
  • DNA
  • Titanium