Abstract
This article acquaints the reader with disorders of the skin that might mimic systemic sclerosis but whose pathology is localized to the skin and/or has extracutaneous manifestations that are different than systemic sclerosis. These disorders include localized scleroderma (morphea), eosinophilic fasciitis, scleredema, scleromyxedema, nephrogenic systemic fibrosis, and chronic graft-versus-host disease. Particular emphasis is placed on clinical and histopathologic features that help the clinician differentiate between these disorders. Treatment options are briefly reviewed.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Chronic Disease
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Diagnosis, Differential
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Eosinophilia / diagnosis
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Eosinophilia / physiopathology
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Fasciitis / diagnosis
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Fasciitis / physiopathology
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Graft vs Host Disease / diagnosis
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Graft vs Host Disease / physiopathology
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Humans
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Interdisciplinary Communication
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Nephrogenic Fibrosing Dermopathy / diagnosis
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Nephrogenic Fibrosing Dermopathy / physiopathology
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Scleredema Adultorum / diagnosis
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Scleredema Adultorum / physiopathology
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Scleroderma, Localized / diagnosis
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Scleroderma, Localized / physiopathology
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Scleroderma, Systemic / diagnosis*
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Scleroderma, Systemic / physiopathology
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Scleromyxedema / diagnosis
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Scleromyxedema / physiopathology
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Skin Diseases / diagnosis*
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Skin Diseases / physiopathology
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Skin Diseases / therapy