It's the peptide-MHC affinity, stupid

Thomas Kammertoens; Thomas Blankenstein

doi:10.1016/j.ccr.2013.04.004

It's the peptide-MHC affinity, stupid

Cancer Cell. 2013 Apr 15;23(4):429-31. doi: 10.1016/j.ccr.2013.04.004.

Authors

Thomas Kammertoens¹, Thomas Blankenstein

Affiliation

¹ Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.

PMID: 23597560
DOI: 10.1016/j.ccr.2013.04.004

Abstract

Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.

Publication types

Comment
Research Support, Non-U.S. Gov't