Objective: To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro.
Method: The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets.
Result: Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen.
Conclusion: Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.