High-dose daptomycin monotherapy cures Staphylococcus epidermidis 'endotipsitis' after failure of conventional therapy

Julia Marie Colston; Matthew Scarborough; Jane Collier; Ian C J W Bowler

doi:10.1136/bcr-2013-009529

High-dose daptomycin monotherapy cures Staphylococcus epidermidis 'endotipsitis' after failure of conventional therapy

BMJ Case Rep. 2013 Apr 16:2013:bcr2013009529. doi: 10.1136/bcr-2013-009529.

Authors

Julia Marie Colston¹, Matthew Scarborough, Jane Collier, Ian C J W Bowler

Affiliation

¹ Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, Oxford, UK. jcolston@doctors.org.uk

Abstract

A 67-year-old gentleman developed persistent Staphylococcus epidermidis bacteraemia following transjugular intrahepatic portal shunting. 'Endotipsitis' was diagnosed. Conventional therapy with a vancomycin infusion, amikacin and rifampicin failed after 17 days. He was cured with a 6-week course of high-dose (8 mg/kg) daptomycin monotherapy.

Publication types

Case Reports

MeSH terms

Aged
Amikacin / therapeutic use
Anti-Bacterial Agents / therapeutic use*
Bacteremia / drug therapy*
Bacteremia / microbiology
Catheterization, Central Venous / adverse effects*
Catheters / microbiology
Daptomycin / therapeutic use*
Drug Resistance, Multiple, Bacterial
Humans
Male
Rifampin / therapeutic use
Staphylococcal Infections / drug therapy*
Staphylococcus epidermidis*
Treatment Failure
Vancomycin / therapeutic use

Substances

Anti-Bacterial Agents
Vancomycin
Amikacin
Daptomycin
Rifampin