Characteristics improvement of calcium hydroxide dental cement by hydroxyapatite nanoparticles. Part 1: formulation and microstructure

Biotechnol Appl Biochem. 2013 Sep-Oct;60(5):502-9. doi: 10.1002/bab.1119. Epub 2013 Sep 3.

Abstract

Calcium hydroxide cement (CHC), which is a direct pulp-capping material, has been widely used for several decades. In spite of the well-known advantages of CHCs, they have some disadvantages as well, such as high solubility, no inherent adhesive qualities, and low mechanical strength. Previous studies were undertaken to improve these deficiencies by implementing changes to modify the conventional CHCs. The aim of the present research is to demonstrate the potential rectification of the aforementioned deficiencies of the commercially available CHCs by adding hydroxyapatite (HA) nanoparticles without lessening their advantages. Here, the synthesized HA nanoparticles were added into the CHCs in two different portions of 3 and 7 wt%. A scanning electron microscope was used to observe and analyze the microstructure, and X-ray energy dispersive analysis was used to analyze the elemental composition of the new CHCs. In addition, setting time, mechanical strength, pH, calcium (Ca) release, and antibacterial behavior were measured to assess how HA nanoparticles influence the characteristics of CHCs. The results showed that adding 3 wt% HA nanoparticles can optimally improve the mechanical strength of the cement and increase the Ca release rate as a mineralization promoter without reducing the antibacterial behavior.

Keywords: antibacterial properties; calcium hydroxide cement; hydroxyapatite; ionic release; nanoparticle.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Calcium / chemistry
  • Calcium / metabolism
  • Calcium Hydroxide / chemistry*
  • Dental Cements / chemistry*
  • Durapatite / chemical synthesis
  • Durapatite / chemistry*
  • Durapatite / pharmacology
  • Hydrogen-Ion Concentration
  • Microbial Sensitivity Tests
  • Nanoparticles / chemistry*
  • Particle Size
  • Streptococcus mutans / drug effects
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Dental Cements
  • Durapatite
  • Calcium Hydroxide
  • Calcium