Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects

PLoS One. 2013 Apr 9;8(4):e61153. doi: 10.1371/journal.pone.0061153. Print 2013.

Abstract

Background: Although adiponectin -11377CG gene polymorphism is implied to be associated with increased type 2 diabetes mellitus (T2DM) risk, results of individual studies are inconsistent.

Objective and methods: A meta-analysis consisting of 12 individual studies, including a total of 6425 participants, was carried out in order to investigate the association of adiponectin -11377CG gene polymorphism with T2DM. The pooled odds ratio (OR) and its corresponding confidence interval (CI) at 95% were assessed through the random- or fixed- effect model.

Results: A significant relationship was observed between adiponectin -11377CG gene polymorphism and T2DM under allelic (OR: 1.150, 95% CI: 1.060 to 1.250, P = 0.001), recessive (OR: 1.450, 95% CI: 1.180-1.770, P = 0.0004), dominant (OR: 1.071, 95% CI: 1.013-1.131, P = 0.015), additive (OR: 1.280, 95% CI: 1.090-1.510, P = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310-1.990, P<0.00001). No significant association was found between them under the heterozygous genetic model (OR: 1.640, 95% CI: 0.850-3.170, P = 0.140).

Conclusions: Adiponectin -11377CG gene polymorphism was significantly associated with T2DM risk susceptibility. G allele carriers are predisposed to T2DM risk.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions*
  • Adiponectin / genetics*
  • Adult
  • Aged
  • Alleles
  • Asian People
  • Diabetes Mellitus, Type 2 / ethnology
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*

Substances

  • 5' Untranslated Regions
  • ADIPOQ protein, human
  • Adiponectin

Grants and funding

This work was funded by the National Natural Science Foundation of China (NSFC 81100073 to Dr Yan-yan Li) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.