Abstract
Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreatic α-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Butylene Glycols / chemistry
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Butylene Glycols / isolation & purification
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Butylene Glycols / pharmacology*
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Flax / chemistry*
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Glycoside Hydrolase Inhibitors
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Intestines / enzymology
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology*
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Molecular Structure
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Pancreatic alpha-Amylases / antagonists & inhibitors*
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Pancreatic alpha-Amylases / metabolism
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Plant Extracts / chemistry*
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Rats
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Structure-Activity Relationship
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Swine
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alpha-Glucosidases / metabolism
Substances
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Butylene Glycols
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Enzyme Inhibitors
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Glucosides
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Glycoside Hydrolase Inhibitors
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Lignans
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Plant Extracts
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Pancreatic alpha-Amylases
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alpha-Glucosidases
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secoisolariciresinol