Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome

J Antimicrob Chemother. 2013 Aug;68(8):1926-8. doi: 10.1093/jac/dkt117. Epub 2013 Apr 11.
No abstract available

Keywords: cardiolipin synthetase; hypercalcaemia; whole-genome sequencing.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Daptomycin / pharmacology
  • Daptomycin / therapeutic use*
  • Drug Resistance, Bacterial*
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / genetics*
  • Enterococcus faecium / isolation & purification
  • Female
  • Genome, Bacterial
  • Gram-Positive Bacterial Infections / drug therapy
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Mutation*
  • Sequence Analysis, DNA
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / microbiology
  • Thyroid Neoplasms / complications

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Daptomycin