Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ

Mikhail V Tsurkan; Karolina Chwalek; Silvana Prokoph; Andrea Zieris; Kandice R Levental; Uwe Freudenberg; Carsten Werner

doi:10.1002/adma.201300691

Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ

Adv Mater. 2013 May 14;25(18):2606-10. doi: 10.1002/adma.201300691. Epub 2013 Apr 10.

Authors

Mikhail V Tsurkan¹, Karolina Chwalek, Silvana Prokoph, Andrea Zieris, Kandice R Levental, Uwe Freudenberg, Carsten Werner

Affiliation

¹ Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany.

PMID: 23576312
DOI: 10.1002/adma.201300691

Abstract

Poly(ethylene glycol)-peptide- and glycosaminoglycan-peptide conjugates obtained by a regio-selective amino acid protection strategy are converted into cell-instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells and dorsal root ganglia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology*
Heparin / chemistry*
Human Umbilical Vein Endothelial Cells / cytology
Human Umbilical Vein Endothelial Cells / drug effects
Humans
Peptides / chemistry*
Polyethylene Glycols / chemistry*
Sulfhydryl Compounds / chemistry

Substances

Biocompatible Materials
Peptides
Sulfhydryl Compounds
Polyethylene Glycols
Heparin