One-step synthesis of peptide-programmed QDs as ready-to-use nanoprobes

Chem Commun (Camb). 2013 May 18;49(40):4492-4. doi: 10.1039/c3cc40524a. Epub 2013 Apr 11.

Abstract

We developed a facile one-step method to produce ready-to-use quantum dots based on a peptide sequence containing a hexahistidine(his6-tag), poly(ethylene glycol) (PEG), and a functional group, which lead to stable and customized peptide-QDs conjugates that could serve as fluorescent nanoprobes for biological imaging and detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / pharmacology
  • Humans
  • Nanoparticles / chemistry*
  • Particle Size
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Quantum Dots*
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Fluorescent Dyes
  • Peptides