Nanoporous organosilica membranes are successfully coated on porous alumina tubes and tested for desalination via membrane distillation. The membranes produced pure water (up to 13 kg m(-2) h(-1)) across an extreme range of salt concentrations (10-150 g L(-1) NaCl) at moderate temperatures (≤60 °C) without exhibiting the characteristic flux decay of competing materials.