New players to the field of ADP-ribosylation make the final cut

Jamin D Steffen; John M Pascal

doi:10.1038/emboj.2013.83

New players to the field of ADP-ribosylation make the final cut

EMBO J. 2013 May 2;32(9):1205-7. doi: 10.1038/emboj.2013.83. Epub 2013 Apr 9.

Authors

Jamin D Steffen¹, John M Pascal

Affiliation

¹ Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

Abstract

EMBO J (2013) 32 9, 1225–1237. doi:; DOI: 10.1038/emboj.2013.51

ADP-ribose-based intermediates, including PARP-generated mono- and poly(ADP-ribose) post-translational modifications, are important to a number of cellular signalling processes. The reversal of poly(ADP-ribosyl)ation is mostly attributed to PARG, which however cannot remove the final protein-linked mono(ADP-ribose) residue. Three recent studies, one of them in The EMBO Journal, now report that certain macrodomains remove terminal ADP-ribose modifications from acidic residues.

Publication types

Comment

MeSH terms

Female
Glycoside Hydrolases / physiology*
Humans
Male
Neurodegenerative Diseases / enzymology*
Poly Adenosine Diphosphate Ribose / physiology*
Thiolester Hydrolases / physiology*

Substances

Poly Adenosine Diphosphate Ribose
OARD1 protein, human
Thiolester Hydrolases
Glycoside Hydrolases