Goniolandrene A and B from Goniothalamus macrophyllus

Norkamilah Abdullah; Hamidah Sahibul-Anwar; Sharinah Ideris; Tomoyo Hasuda; Yukio Hitotsuyanagi; Koichi Takeya; Marc Diederich; CheeYan Choo

doi:10.1016/j.fitote.2013.03.028

Goniolandrene A and B from Goniothalamus macrophyllus

Fitoterapia. 2013 Jul:88:1-6. doi: 10.1016/j.fitote.2013.03.028. Epub 2013 Apr 6.

Authors

Norkamilah Abdullah¹, Hamidah Sahibul-Anwar¹, Sharinah Ideris¹, Tomoyo Hasuda², Yukio Hitotsuyanagi², Koichi Takeya², Marc Diederich³, CheeYan Choo⁴

Affiliations

¹ MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
² Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan.
³ Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg.
⁴ MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. Electronic address: choo715@puncakalam.uitm.edu.my.

PMID: 23570840
DOI: 10.1016/j.fitote.2013.03.028

Abstract

Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compounds with two new compounds, namely goniolandrene-A (1), -B (2). The absolute configuration of goniolandrene B (2) was established by circular dichrosim. The compounds were cytotoxic against the P388 cells with IC50 values ranging from 0.42 to 160 μM. Goniothalamin (3) exhibited the highest inhibition of 0.42 μM.

Keywords: Annonaceae; Biogenetic pathway; Cytotoxicity; G. macrophyllus; Goniolandrene; P388.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Benzofurans / chemistry
Benzofurans / isolation & purification*
Benzofurans / pharmacology
Benzofurans / therapeutic use
Cell Line, Tumor
Chromones / chemistry
Chromones / isolation & purification*
Chromones / pharmacology
Chromones / therapeutic use
Goniothalamus / chemistry*
Heterocyclic Compounds, 3-Ring / chemistry
Heterocyclic Compounds, 3-Ring / isolation & purification*
Heterocyclic Compounds, 3-Ring / pharmacology
Heterocyclic Compounds, 3-Ring / therapeutic use
Inhibitory Concentration 50
Leukemia P388 / drug therapy
Malaysia
Molecular Structure
Phytotherapy
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plant Roots
Pyrones / chemistry
Pyrones / isolation & purification*
Pyrones / pharmacology
Pyrones / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Benzofurans
Chromones
Heterocyclic Compounds, 3-Ring
Plant Extracts
Pyrones
goniolandrene-A
goniolandrene-B