4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Bioorg Med Chem Lett. 2013 May 15;23(10):3001-6. doi: 10.1016/j.bmcl.2013.03.031. Epub 2013 Mar 21.

Abstract

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

MeSH terms

  • Animals
  • Chloride Channels / antagonists & inhibitors*
  • Chloride Channels / metabolism
  • Dose-Response Relationship, Drug
  • Insecta
  • Insecticides / chemical synthesis
  • Insecticides / chemistry
  • Insecticides / pharmacology*
  • Isoxazoles / chemical synthesis
  • Isoxazoles / chemistry
  • Isoxazoles / pharmacology*
  • Molecular Structure
  • Receptors, GABA / metabolism*
  • Structure-Activity Relationship

Substances

  • 4-azolylphenyl isoxazoline
  • Chloride Channels
  • Insecticides
  • Isoxazoles
  • Receptors, GABA