Abstract
Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Chloride Channels / antagonists & inhibitors*
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Chloride Channels / metabolism
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Dose-Response Relationship, Drug
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Insecta
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Insecticides / chemical synthesis
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Insecticides / chemistry
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Insecticides / pharmacology*
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Isoxazoles / chemical synthesis
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Isoxazoles / chemistry
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Isoxazoles / pharmacology*
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Molecular Structure
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Receptors, GABA / metabolism*
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Structure-Activity Relationship
Substances
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4-azolylphenyl isoxazoline
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Chloride Channels
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Insecticides
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Isoxazoles
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Receptors, GABA