Abstract
A series of N-substituted-1,2,3-triazole murrayafoline A derivatives were successfully synthesized using click azide-alkyne Huisgen cycloaddition reaction between 1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole and substituted alkynes. Their chemical structures were confirmed by (1)H, (13)C NMR and HR-ESI-MS spectral data. In addition, the interested effects on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells of synthetic murrayafoline A derivatives were also investigated. Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-α.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Bone Marrow Cells / drug effects*
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Bone Marrow Cells / metabolism
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology
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Cells, Cultured
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Cytokines / antagonists & inhibitors*
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Cytokines / biosynthesis
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Dendritic Cells / drug effects*
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Dendritic Cells / metabolism
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Dose-Response Relationship, Drug
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Inflammation Mediators / antagonists & inhibitors*
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Inflammation Mediators / physiology
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Lipopolysaccharides / toxicity
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Mice
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Mice, Inbred C57BL
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Plant Roots
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Rutaceae
Substances
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Alkaloids
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Anti-Inflammatory Agents, Non-Steroidal
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Carbazoles
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Cytokines
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Inflammation Mediators
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Lipopolysaccharides
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murrayafoline A