Copper-catalyzed aerobic oxidative synthesis of aryl nitriles from benzylic alcohols and aqueous ammonia

Org Biomol Chem. 2013 May 28;11(20):3349-54. doi: 10.1039/c3ob00002h.

Abstract

Copper-catalyzed direct conversion of benzylic alcohols to aryl nitriles was realized using NH3(aq.) as the nitrogen source, O2 as the oxidant and TEMPO as the co-catalyst. Furthermore, copper-catalyzed one-pot synthesis of primary aryl amides from alcohols was also achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ammonia / chemistry*
  • Benzyl Alcohols / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Molecular Structure
  • Nitrates / chemistry*
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry
  • Oxidation-Reduction
  • Water / chemistry

Substances

  • Benzyl Alcohols
  • Nitrates
  • Nitriles
  • Water
  • Ammonia
  • Copper
  • copper(II) nitrate