Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats

Pharmacol Rep. 2013;65(1):214-9. doi: 10.1016/s1734-1140(13)70981-2.

Abstract

Background: The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg).

Methods: Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu.

Results: Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1st, 2nd and 3rd h from the carrageenan injection.

Conclusions: ZHA enhanced the anti-inflammatory effect of ketoprofen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Analgesics / administration & dosage
  • Analgesics / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Aspartic Acid / administration & dosage
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Carrageenan
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Edema / drug therapy
  • Edema / pathology
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism
  • Inflammation / drug therapy*
  • Inflammation / pathology
  • Injections, Intraperitoneal
  • Ketoprofen / administration & dosage
  • Ketoprofen / pharmacology*
  • Male
  • Organometallic Compounds / administration & dosage
  • Organometallic Compounds / pharmacology*
  • Rats
  • Rats, Wistar
  • Zinc / administration & dosage
  • Zinc / pharmacology*
  • Zinc Compounds / administration & dosage
  • Zinc Compounds / pharmacology*

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Organometallic Compounds
  • Zinc Compounds
  • zinc-bis(hydrogenaspartate)
  • Aspartic Acid
  • Carrageenan
  • Ketoprofen
  • Zinc