Abstract
Background:
The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg).
Methods:
Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu.
Results:
Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1st, 2nd and 3rd h from the carrageenan injection.
Conclusions:
ZHA enhanced the anti-inflammatory effect of ketoprofen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Analgesics / administration & dosage
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Analgesics / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Aspartic Acid / administration & dosage
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / pharmacology
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Carrageenan
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Edema / drug therapy
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Edema / pathology
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Gastric Mucosa / drug effects
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Gastric Mucosa / metabolism
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Inflammation / drug therapy*
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Inflammation / pathology
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Injections, Intraperitoneal
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Ketoprofen / administration & dosage
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Ketoprofen / pharmacology*
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Male
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / pharmacology*
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Rats
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Rats, Wistar
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Zinc / administration & dosage
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Zinc / pharmacology*
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Zinc Compounds / administration & dosage
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Zinc Compounds / pharmacology*
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Organometallic Compounds
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Zinc Compounds
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zinc-bis(hydrogenaspartate)
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Aspartic Acid
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Carrageenan
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Ketoprofen
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Zinc