STAT signaling in different breast cancer sub-types

Abstract

This review summarizes information on expression of Signal Transducer and Activator of Transcription (STAT)s 1, 2, 3, 4, 5a/b and 6 in cancer cells from different human breast cancer sub-types. STAT proteins, especially STATs 1, 3 and 5a/b are expressed in some but not all cancers from all of the different major breast cancer sub-types. However, well-designed studies comparing expression patterns at the protein level in cancer and surrounding stromal cells are still needed to fully examine links with prognosis and therapeutic response. Moreover, it is not yet known if distinct expression patterns of STAT proteins could have dissimilar impacts in different sub-types, especially between the luminal A and B ER+ sub-types and the different TNBC sub-types. Recent data indicating that STAT 5 can be activated secondary to a therapeutic intervention and mediate resistance suggests that expression patterns should not only be examined in pre-treatment but also post-treatment samples from different sub-types.

Keywords: Breast cancer sub-types; ER; ER+ breast cancer; Estrogen Receptor; HER2; HER2 amplified breast cancer; IL; JAK; Janus Kinase; PI3K; STAT; Signal Transducer and Activator of Transcription; Signal Transducer and Activator of Transcription (STAT); TNBC; Triple Negative Breast Cancer; Triple negative breast cancer; human epidermal growth factor 2; interleukin; mTOR; mammalian target of rapamycin; phosphatidylinositol 3-kinase.