Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

Xiang Li; Ye Tian; Sheng-Xiang Yang; Ya-Mei Zhang; Jian-Chun Qin

doi:10.1016/j.bmcl.2013.03.044

Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

Bioorg Med Chem Lett. 2013 May 15;23(10):2945-7. doi: 10.1016/j.bmcl.2013.03.044. Epub 2013 Mar 21.

Authors

Xiang Li¹, Ye Tian, Sheng-Xiang Yang, Ya-Mei Zhang, Jian-Chun Qin

Affiliation

¹ College of Plant Sciences, Jilin University, Changchun, 130062 Jilin, China.

PMID: 23562244
DOI: 10.1016/j.bmcl.2013.03.044

Abstract

Three novel azaphilone alkaloids, namely chaetomugilides A-C (1-3), together with three related compounds (4-6) were isolated from the methanol extract of Chaetomium globosum TY1, an endophytic fungus isolated from Ginkgo biloba. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. The isolated compounds exhibited highly cytotoxic activities against human cancer cell line HePG2 with the IC50 values range from 1.7 to 53.4μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Benzopyrans / chemistry
Benzopyrans / isolation & purification
Benzopyrans / pharmacology*
Chaetomium / chemistry*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Molecular Structure
Pigments, Biological / chemistry
Pigments, Biological / isolation & purification
Pigments, Biological / pharmacology*
Structure-Activity Relationship

Substances

Alkaloids
Antineoplastic Agents
Benzopyrans
Pigments, Biological
azaphilone
chaetomugilide A
chaetomugilide B
chaetomugilide C