Toxicological evaluation of magnetic ionic liquids in human cell lines

Chemosphere. 2013 Jun;92(1):100-5. doi: 10.1016/j.chemosphere.2013.02.047. Epub 2013 Apr 3.

Abstract

Magnetic ionic liquids (MILs) are new solvents with an interesting broad of applications however their toxicity is still an open issue. In this paper we report the toxicity of [C(8)MIM] and [Choline-C(n)] based magnetic ionic liquids assessed in two human cell lines: normal skin fibroblasts (CRL-1502) and colorectal adenocarcinoma cells (CaCo-2), acquiring this last characteristics of human enterocytes after differentiation. The results showed that [CoCl(4)] and [MnCl(4)] are more prone to generate cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caco-2 Cells
  • Cell Line
  • Cell Survival / drug effects
  • Chlorides / chemistry
  • Chlorides / toxicity
  • Cobalt / chemistry
  • Cobalt / toxicity
  • Environmental Pollutants / chemistry
  • Environmental Pollutants / toxicity*
  • Humans
  • Ionic Liquids / chemical synthesis
  • Ionic Liquids / chemistry
  • Ionic Liquids / toxicity*
  • Magnetics*
  • Manganese Compounds / chemistry
  • Models, Chemical
  • Solvents / chemistry

Substances

  • Chlorides
  • Environmental Pollutants
  • Ionic Liquids
  • Manganese Compounds
  • Solvents
  • Cobalt
  • cobaltous chloride
  • manganese chloride